Targetting the Kinase PAK1 in Colorectal Cancer

Grant number: 1041831 | Funding period: 2013 - 2016

Completed

Abstract

This project aims to develop a new therapy for colorectal cancer (CRC). We have already demonstrated that a molecule called PAK1 is the master regulator of several intracellular signalling pathways, and is essential for CRC growth and invasion. We now plan to study whether inhibitors that block PAK1 activity can prevent the growth of human CRC cells in the laboratory or their development into tumours in animals.

Related publications (6)

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PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines

K Wang, N Huynh, X Wang, M Pajic, A Parkin, J Man, GS Baldwin, M Nikfarjam, H He

2019-01-01

Background/objective: Pancreatic ductal adenocarcinoma (PDA) remains the most lethal malignancy due to lack of an effective treatm..

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Inhibition of p21 activated kinase enhances tumour immune response and sensitizes pancreatic cancer to gemcitabine

K Wang, N Huynh, X Wang, G Baldwin, M Nikfarjam, H He

2018-01-01

Pancreatic ductal adenocarcinoma (PDA) is one of the major types of cancer that exhibit high mortality worldwide because of the la..

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Depletion of p21-activated kinase 1 up-regulates the immune system of APCΔ14/ mice and inhibits intestinal tumorigenesis

N Huynh, K Wang, M Yim, CJ Dumesny, MS Sandrin, GS Baldwin, M Nikfarjam, H He

2017-06-19

Background: P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multip..

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Up-regulation of stem cell markers by P21-activated kinase 1 contributes to 5-fluorouracil resistance of colorectal cancer

N Huynh, A Shulkes, G Baldwin, H He

2016-08-02

Cancer stem cells (CSC) are tumorigenic and resistant to chemotherapy. In colorectal cancer (CRC), CSCs have been identified by th..

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Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway

N Huynh, JA Beutler, A Shulkes, GS Baldwin, H He

2015-01-01

p-21-Activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by stimulating Wnt/β-catenin, ERK and AKT pathways. PA..

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Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases

D Yeo, N Huynh, JA Beutler, C Christophi, A Shulkes, GS Baldwin, M Nikfarjam, H He

2014-05-01

Pancreatic cancer is one of the most lethal of human malignancies. Nearly 100% cases of pancreatic cancer carry mutations in KRas...

University of Melbourne Researchers